CO-rebreathing technique safe for patients with coronary artery disease

Forsker ved CERG Trine KarlsenThe CO-rebreathing technique for measuring total blood volume and hemoglobin mass is safe to perform in stable coronary artery disease patients having completed cardiac rehabilitation. Trine Karlsen and colleagues show this in a resent study ”Safety of the CO-Rebreathing Method in Patients with Coronary Artery Disease”, published in the Medicine and Science in Sports and Exercise Journal.

“The aim of the study was to investigate the use of this methodology in stable coronary artery disease patients to allow for an implementation of the methodology in this patient group”, Karlsen says. Knowledge of total blood volume and absolute hemoglobin mass is vital when evaluating cardiovascular physiology and function, as well as physical activity performance.

The improved CO-rebreathing methodology, developed by Schmidt and Prommer in 2005, is commonly used in athletes and healthy individuals, but has been used to a limited degree ischemic patient populations. This is due to the 6 % reduction in oxygen bound to hemoglobin in the red blood cells. The methodology is highly accurate, and is currently the least invasive methodology available.

Read also: Physical activity should be a central part of coronary artery disease treatment

Eighteen stable coronary artery disease patients were studied with the CO-rebreathing test to detect total blood- and plasma volume, erythrocyte volume and total hemoglobin mass. Heart function, blood pressure and heart rhythm were closely followed for two hours after the procedure. Twenty-four hours after the CO-test, high sensitive troponin-T was measured.

Read also: Can e-cigarettes reduce smoking?

Patients were in sinus rhythm during the 2-h observation period. There were no ST- or T-wave changes. Patients had a low numbers of premature beats and normal rate variability. Systolic and diastolic blood pressure gradually decreased as the patients were resting during the observation period. Troponin-T was below the 99th percentile for all the participants 24 h after the test. The paper gives a detailed description of the patient demographics, as the results of the study are limited to the patient population.

Read also: What is your cholesterol? – Know your number!

The authors concluded that the CO-rebreathing test performed according to the protocol was safe to perform in stable coronary artery disease patients when the percentage of CO bound to hemoglobin increased to approximately 6%.

Trine Karlsen, Researcher at CERG

 

 

This entry was posted in Cardiovascular disease, In English, Publications and tagged , by CERG. Bookmark the permalink.

About CERG

The Cardiac Exercise Research Group (CERG) at the Norwegian University of Science and Technology (NTNU) seeks to identify the key mechanisms underlying the beneficial effects of physical on cardiac health in the context of disease prevention and treatment. Named the K.G. Jebsen Center for Exercise in Medicine under Professor Ulrik Wisløff's leadership in 2011, CERG uses both top-down and bottom-up approaches to combat lifestyle-related disease.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s